![]() ![]() ![]() 8 Panacinar emphysema is commonly associated with α 1-antitrypsin deficiency, but is also found in cases where no clearcut genetic abnormality has been identified.ĭistal acinar, mantle, and paraseptal emphysema are terms used to describe lesions that occur in the periphery of the lobule along the lobular septae, particularly in the subpleural region. In contrast to the centrilobular lesion, panacinar emphysema is more severe in the lower lobes but a predominant lower lobe distribution only becomes statistically significant in severe disease. 11 Thurlbeck 8 showed that, in its mildest forms, it is difficult to discern PLE from normal lung unless the lung is fixed in full inflation and carefully examined using low power magnification. Panlobular or panacinar emphysema (PLE) results from a more uniform destruction of all of the acini within the secondary lobule. ![]()
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